Research Article
Prognostic Impact of Tumor Budding on Moroccan Colon Cancer Patients
Table 6
Association between tumor budding and molecular biomarkers.
| Variables | Low-grade tumor budding | High-grade tumor budding | value |
| MSI status | | | 0.005 | MSS | 42 (70.0%) | 37 (92.5%) | MSI | 18 (30.0%) | 3 (7.5%) | KRAS status | | | | Mutant | 14 (23.3%) | 17 (42.5%) | 0.02 | Wild-type | 46 (76.7%) | 23 (57.5%) | | KRAS codon types | | | | Codon 12 | 7 (50%) | 12 (70.6%) | 0.05 | Codon 13 | 5 (35.7%) | 4 (23.5%) | | Codon 146 | 2 (14.3%) | 1 (5.9%) | | KRAS codon 12 variants | | | | G12D | 1 (14.3%) | 10 (83.3%) | 0.007 | G12C | 2 (28.6%) | 2 (16.7%) | | G12V | 2 (28.6%) | 0 (0.0%) | | G12A | 1 (14.3%) | 0 (0.0%) | | G12R | 1 (14.3%) | 0 (0.0%) | | KRAS codon 13 variants | | | | G13D | 4 (80%) | 4 (100%) | 0.3 | G13V | 1 (20%) | 0 (0.0%) | | NRAS gene status | | | 0.4 | Mutant | 1 (1.7%) | 1 (2.5%) | Wild-type | 59 (98.3%) | 59 (97.5%) |
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