International Journal of Surgical Oncology / 2022 / Article / Tab 6 / Research Article
High CD44 Immunoexpression Correlates with Poor Overall Survival: Assessing the Role of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma Patients from the High-Risk Population of Pakistan Table 6 Cox regression univariate analysis (n = 100).
Characteristic Overall survival Disease-free survival Hazard ratio 95% CI Hazard ratio 95% CI HR Lower Upper HR Lower Upper Gender 100 100 Male 1.0 (ref) 1.0 (ref) Female 0.598 1.154 0.678 1.962 0.632 0.893 0.562 1.419 Age division 100 100 < 40 Years 1.0 (ref) 1.0 (ref) > 40 Years0.931 0.969 0.472 1.987 0.381 0.769 0.427 1.385 Primary tumour site 100 100 Tongue 1.0 (ref) 1.0 (ref) Cheek 0.291 0.738 0.419 1.297 0.049 1.655 1.002 2.734 Tonsil 100 100 No 1.0 (ref) 1.0 (ref) Yes 0.004 8.999 2.016 40.167 0.007 7.691 1.731 34.18 Skin 100 100 No 1.0 (ref) 1.0 (ref) Yes 0.097 2.699 0.836 8.718 0.045 3.316 1.029 10.69 Primary margins 100 100 Clear 0.007 1.0 (ref) 0.11 1.0 (ref) Near 0.045 1.856 1.014 3.396 0.109 1.535 0.909 2.594 Involved 0.003 3.091 1.454 6.572 0.004 2.756 1.372 5.537 T classification 100 100 T1 0.135 1.0 (ref) 0.156 1.0 (ref) T2 0.215 1.655 0.746 3.675 0.39 1.324 0.698 2.512 T3 0.085 2.23 0.896 5.548 0.162 1.732 0.802 3.743 T4 0.027 2.803 1.124 6.991 0.034 2.28 1.066 4.874 N classification 100 100 N0 <0.001 1.0 (ref) 0.031 1.0 (ref) N1 0.004 2.888 1.415 5.89 0.082 1.833 0.925 3.635 N2 <0.001 4.148 1.89 9.103 0.025 2.364 1.114 5.018 AJCC stage 100 100 I 0.004 1.0 (ref) 0.038 1.0 (ref) II 0.345 1.579 0.612 4.075 0.436 1.329 0.65 2.717 III 0.033 2.789 1.088 7.129 0.143 1.755 0.827 3.726 IV 0.002 4.259 1.681 10.792 0.009 2.644 1.269 5.512 Radiotherapy 100 100 Yes 1.0 (ref) 1.0 (ref) No 0.029 1.950 1.071 3.552 0.247 0.749 0.459 1.222 CD44 100 100 Low 1.0 (ref) 1.0 (ref) High 0.051 1.71 0.999 2.927 0.246 1.346 0.815 2.223 CD133 100 100 Negative 1.0 (ref) 1.0 (ref) Positive 0.615 0.837 0.418 1.676 0.996 0.998 0.568 1.756 L1CAM 100 100 Negative 1.0 (ref) 1.0 (ref) Positive 0.491 1.208 0.706 2.066 0.272 1.304 0.812 2.092 SOX2 100 100 Negative 1.0 (ref) 1.0 (ref) Positive 0.321 1.247 0.668 2.325 0.265 1.364 0.79 2.353