Angiopoietin-2 Is Associated with Aortic Stiffness in Diabetes Patients in Ghana: A Case-Control Study

Table 4

Association between angiogenic growth factors and indices of aortic stiffness from multiple linear regression models.

Aortic indices	Growth factor	Age- and sex-adjusted model		Multivariable model
		PWV		Ang-1	0.069	0.32	-0.016	0.82
Ang-2	0.162		0.03	0.148	0.03
VEGF	0.006		0.93	-0.01	0.89
AIx	Ang-1	0.039	0.58	0.032	0.63
	Ang-2	0.147	0.03	0.188	<0.01
	VEGF	0.033	0.96	0.073	0.28
Systolic BP	Ang-1	0.156	0.03	0.049	0.51
	Ang-2	0.274	<0.01	0.222	<0.01
	VEGF	0.057	0.44	0.07	0.33

All of the angiogenic growth factors are logarithmically transformed. Ang-1: angiopoietin 1; Ang-2: angiopoietin 2; VEGF: vascular endothelial growth factor; BP: blood pressure; PWV: aortic pulse wave velocity; AIx: aortic augmentation index. Multivariable models were adjusted for age, sex, diabetes status, hypertension status, body mass index, heart rate, total cholesterol, triglycerides, and mean blood pressure. : standardized regression coefficient.