Research Article
Development and Validation of Analytical Procedure for Elemental Impurities in Rosuvastatin Calcium Tablets by ICP-MS and Microwave Digestion
Table 4
Digestion procedure optimization.
| | Acid added into the digestion tank | Mixture’s state after digestion | Mixture’s final state after dilution |
| 1 | 5 mL of nitric acid | Muddy | Muddy | 2 | 10 mL of nitric acid | Muddy | Muddy | 3 | 9 mL of nitric acid plus 3 mL of hydrochloric acid | Muddy | Muddy | 4 | 10 mL of nitric acid plus 2 mL of 30% hydrogen peroxide | Muddy | Muddy | 5 | 5 mL of nitric acid plus 1 mL of concentrated sulfuric acid | Muddy | Muddy | 6 | 5 mL of nitric acid plus 0.04 mL of hydrofluoric acid | Clear | Muddy | 7 | 5 mL of nitric acid plus 0.05 mL of hydrofluoric acid | Clear | Clear | 8 | 5 mL of nitric acid plus 0.06 mL of hydrofluoric acid | Clear | Clear | 9 | 5 mL of nitric acid plus 0.1 mL of hydrofluoric acid | Clear | Clear | 10 | 5 mL of nitric acid plus 0.5 mL of hydrofluoric acid | Clear | Clear |
|
|