Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems

Table 4

pH and spreading time of ointment formulations.

Formulations	pH	Spreading time (sec)
OB	6.3 ± 0.62	28.8 ± 1.86
ACO1	6.2 ± 0.02	25.9 ± 3.22
ACO2	6.5 ± 0.17	24.6 ± 6.03
ACO3	6.8 ± 0.13	22.9 ± 1.27
MCO1	6.6 ± 0.22	22.2 ± 3.16
MCO2	6.8 ± 0.51	21.4 ± 0.10
MCO3	6.7 ± 0.16	21.2 ± 0.73
ASO1	6.5 ± 0.11	18.9 ± 2.27
ASO2	6.3 ± 0.32	18.1 ± 5.14
ASO3	6.1 ± 0.72	16.6 ± 1.04
MSO1	6.0 ± 0.27	15.0 ± 2.30
MSO2	6.1 ± 0.09	15.7 ± 2.02
MSO3	5.9 ± 0.24	13.1 ± 0.62
CO	6.8 ± 0.18	22.3 ± 4.31

Note. OB: ointment base (negative control), ACO1, ACO2, and ACO3: 1%, 1.5%, and 2% aqueous crude extract ointment, respectively, MCO1, MCO2, and MCO3: 1%, 1.5%, and 2% methanol crude extract ointment, respectively, ASO1, ASO2, and ASO3: 1%, 1.5%, and 2% aqueous SNPs ointment, respectively, MSO1, MSO2, and MSO3: 1%, 1.5%, and 2% methanol SNPs ointment, respectively, and CO: 1% ciprofloxacin ointment (positive control).