miR-21 Targets ASPP2 to Inhibit Apoptosis via CHOP-Mediated Signaling in Helicobacter pylori-Infected Gastric Cancer Cells

Figure 7

Decreased ASPP2 expression is associated with poor prognosis in HPGC. (a) Relative ASPP2 expression levels in gastric tissues from different stages of Correa’s cascade, including HP (−) healthy control (n = 30), HPGS (n = 30), HPIM (n = 29), and HPGC (n = 57) by IHC. Upper, representative images were captured at 200x magnification. Scale bar, 50 μm. Lower, relative quantitation of ASPP2 levels by H score ranking. The significance of differences in H score between two groups was compared using the nonparametric Mann–Whitney U test. (b) Kaplan–Meier OS curves for 92 HPGC patients stratified by ASPP2 expression were constructed using the Kaplan–Meier method and compared with the log-rank test.  < 0.001.

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