miR-21 Targets ASPP2 to Inhibit Apoptosis via CHOP-Mediated Signaling in Helicobacter pylori-Infected Gastric Cancer Cells
Table 2
HRs of demographic and clinicopathological features and ASPP2 expression in HPGC patients via Cox’s proportional hazards analysis.
Univariate analysis
HR (95% CI)
value
Age
0.178
≥50 years vs. <50 years
1.69 (0.79, 3.66)
Gender
0.732
Male vs. female
0.90 (0.49, 1.64)
Cigarette smoking
0.273
Smoker vs. nonsmoker
1.45 (0.75, 2.83)
Alcohol consumption
0.972
Yes vs. no
0.99 (0.45, 2.16)
Tumor location
0.514
Proximal vs. distal
1.48 (0.46, 4.79)
Lauren classification
0.730
Intestinal type vs. diffuse type
0.89 (0.46, 1.73)
Tumor stage#
<0.001∗∗∗
III and IV vs. I and II
7.67 (3.53, 16.66)
Histological grade
0.169
G3 and G4 vs. G1 and G2
1.72 (0.80, 3.70)
Invasive depth
<0.001∗∗∗
T3 and T4 vs. T1 and T2
7.48 (2.93, 19.10)
Nodal metastasis
<0.001∗∗∗
N2 and N3 vs. N0 and N1
3.16 (1.67, 6.01)
Metastasis
<0.001∗∗∗
M1 vs. M0
18.60 (8.63, 40.11)
ASPP2 expression
<0.01∗∗
Low vs. high
2.62 (1.42, 4.81)
Multivariate analysis
HR (95% CI)
value
Tumor stage#
0.056
III and IV vs. I and II
3.87 (0.97, 15.48)
Invasive depth
0.505
T3 and T4 vs. T1 and T2
1.65 (0.38, 7.10)
Nodal metastasis
0.454
N2 and N3 vs. N0 and N1
0.73 (0.33, 1.65)
Metastasis
<0.001∗∗∗
M1 vs. M0
9.08 (3.90, 21.10)
ASPP2 expression
<0.05∗
High vs. low
2.15 (1.07, 4.31)
Adjusted for age, gender, tumor stage, invasive depth, nodal metastasis, and metastasis. #Tumor stage was defined according to the 7th edition of the American Joint Committee on Cancer Staging. ∗significant at the level of α = 0.05, ∗∗significant at the level of α = 0.01, and ∗∗∗significant at the level of α = 0.001.
