Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations

Figure 3

Comparison of glycan expression based on lectin microarray results between KRAS mutant and KRAS wild-type organoids. (a) List with t values of lectins significantly changed between KRAS mutation positive organoids and KRAS wild organoids. Labels and bars at the top of the figure indicate the type of glycan structure to which each lectin binds. Fucose (Fuc); red bar, Mannose (Man); green bar, Galactose (Gal); orange bar, sialic acid; purple bar, O-glycan; gray bar. Statistically significant differences are calculated by unpaired student’s t test and the lectins with are selected. Lectins are categorized based on their binding specificities. (b) The volcano plot of differential intensity of lectins in KRAS mutation organoids and KRAS wild organoids represents fold change and values of the selected lectins on x- and y-axis, respectively. (Lectins listed in Figure 3(a)) (c) Lists of representative lectins that are listed by type in order of value.

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