Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations

Figure 5

Analysis of glycosyltransferase and glycan expression in organoids established from the same patient. Case1 (a–c), Case2 (d–f). (a, d) Schema indicating the pancreatic lesion of Case1 used for the organoid and mutation site of each organoid. (b, e) Statistically significant differences were calculated by unpaired student’s t test and were selected. Lectins were categorized based on their binding specificities. Data are shown with t values. (c, f) Volcano plot with fold change and values on x- and y-axes, respectively. The vertical line represents a fold-change cutoff of ≥2.0.

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