Molecular Insights into the Breast and Prostate Cancer Cells in Response to the Change of Extracellular Zinc

Figure 1

Differentially expressed protein spots in 2-DE gels by comparisons of MCF-7 T₀ vs MCF10A T₀ and MCF-7 T₁₂₀ vs MCF10A T₁₂₀. (a) Representative 2-DE gel images (in the left panel) of breast normal MCF10A cells (MCF10A T₀) and breast cancer MCF-7 cells (MCF-7 T₀) without zinc exposure (T₀). (b) Representative 2-DE gel images (in the right panel) of breast normal MCF10A cells (MCF10A T₁₂₀) and breast cancer MCF-7 cells (MCF-7 T₁₂₀) with exogenous zinc exposure for 120 min (T₁₂₀). Each protein extract (100 μg) was resolved based on isoelectric point (pI) and molecular weight (MW). The differentially expressed protein spots are shown with red circles denoting upregulation and green circles denoting downregulation.

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