Molecular Insights into the Breast and Prostate Cancer Cells in Response to the Change of Extracellular Zinc

Figure 2

Differentially expressed protein spots in 2-DE gels by comparisons of MCF-7 T₁₂₀ vs MCF-7 T₀ and MCF10A T₁₂₀ vs MCF10A T₀. (a) Representative 2-DE gel images (in the left panel) of breast cancer MCF-7 cells without zinc (MCF-7 T₀) and with exogenous zinc exposure for 120 min (MCF-7 T₁₂₀). (b) Representative 2-DE gel images (in the right panel) of breast normal MCF10A cells without zinc (MCF10A T₀) and with exogenous zinc exposure for 120 min (MCF10A T₁₂₀). Each protein extract (100 μg) extract was resolved based on isoelectric point (pI) and molecular weight (MW). The differentially expressed protein spots are shown with red circles denoting upregulation and green circles denoting downregulation.

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