Chemical, Physical, and Biological Corneal Decellularization Methods: A Review of Literature
Table 3
The summary of biological corneal decellularization methods discussed in this review.
Biological decellularization methods
Advantages/disadvantages
Significance for future research
References
Enzymes
(i) Often used in decellularization protocols to help remove residual genetic material after cell lysis (ii) Must be used with another decellularization method (iii) Can disrupt ECM structure (iv) Less transparent decellularized corneal tissue
(i) Efficient decellularization method (ii) Maintained ultrastructure of decellularized corneal tissue (iii) Good optical properties after decellularization (iv) No need for other decellularization methods