Advanced Periocular Basal Cell Carcinoma with Orbital Invasion: Update on Management and Treatment Advances

Table 1

Baseline demographic and clinical characteristics.

Patient	Age/gender	Histologic subtype	Localization	Primary/recurrent	TNM	Treatment (months)	Margins	Adjuvant therapy (months)	Clinical response	Follow-up(months)	Final outcome
1	42 F	Infiltrative	MC	Recurrent	T4a	Exenteration	Positive	RT	Progression	44	Exitus
2	78 M	Infiltrative	MC	Primary	T4a	Conservative surgery	Negative		CR	60	NED
3	60 F	Infiltrative	MC	Primary	T4a	Conservative surgery	Negative		CR	64	NED
4	75 M	Infiltrative	LC + UE	Recurrent	T4b	Exenteration	Negative		CR	76	NED
5	84 F	Infiltrative	MC + LE	Recurrent	T4b	Exenteration	Negative		CR	72	Exitus
6	85 F	Infiltrative	LE	Recurrent	T4b	Exenteration	Negative		CR	70	Exitus
7	82 M	Infiltrative	LE	Recurrent	T4a	Exenteration	Negative		CR	60	Exitus
8	91 F	Basosquamous	MC + UE + LE + LC	Recurrent	T4a	Exenteration	Negative		CR	36	Exitus
9	77 F	Infiltrative	MC	Recurrent	T4a	Vismodegib (12)			CR	48	NED
10	84 M	Infiltrative	LE	Recurrent	T4a	Conservative surgery	Negative		CR	41	Exitus
11	70 M	Infiltrative	MC	Recurrent	T4b	Exenteration	Negative		CR	60	NED
12	64 M	Infiltrative	MC	Primary	T4a	Conservative surgery	Negative		CR	72	NED
13	72 M	Infiltrative	MC	Primary	T4a	Conservative surgery	Negative		CR	59	NED
14	82 F	Infiltrative	MC	Recurrent	T4a	Exenteration	Negative		CR	44	NED
15	81 F	Infiltrative	MC	Recurrent	T4b	Exenteration	Positive	Vismodegib (8)	CR	42	NED
16	45 M	Infiltrative	MC	Recurrent	T4a	Conservative surgery	Positive	Vismodegib (58)	CR	62	NED
17	57 M	Infiltrative	MC	Recurrent	T4a	Conservative surgery	Negative		CR	60	NED
18	78 F	Infiltrative	MC	Recurrent	T4a	Conservative surgery	Negative		CR	62	NED
19	52 M	Infiltrative	LC + LE	Primary	T4a	Conservative surgery	Negative		CR	54	NED
20	54 M	Infiltrative	LC + LE	Primary	T4a	Conservative surgery	Negative		CR	62	NED
21	79 F	Infiltrative	MC	Recurrent	T4a	Conservative surgery	Positive	Vismodegib (10)	CR	44	NED
22	67 M	Infiltrative	MC	Recurrent	T4a	Vismodegib (3)				12	Exitus
23	95 F	Infiltrative	MC	Primary	T4a	Vismodegib (1)				8	Exitus
24	72 M	Micronodular	MC	Recurrent	T4a	Conservative surgery	Positive	Vismodegib (10)	CR	36	NED

F: female, M: male, TNM: staging tumor node metastasis [19], MC: medial canthus, LC: lateral canthus, UE: upper eyelid, LE: lower eyelid, not due to cancer, due to lung cancer, RT: radiotherapy, CR: complete remission, NED: no evidence of disease.