Research Article
Efficacy and Predictive Factors of Oral Spironolactone Treatment in Chronic Central Serous Chorioretinopathy
Table 3
Comparison of clinical characteristics between the responder group and the nonresponder group with chronic CSC treated with spironolactone.
| | Responder group, 24 eyes | Nonresponder group, 18 eyes | value |
| Demographics | | | | Age (y) | 45.67 ± 5.37 | 46.57 ± 8.23 | 0.71a | Male (n) | 16 | 13 | >0.99b | Hypertension (n) | 8 | 7 | >0.99b | Disease duration (months) | 7.22 ± 3.23 | 7.07 ± 2.73 | 0.89a | Baseline BCVA (logMAR) | 0.17 ± 0.28 | 0.27 ± 0.27 | 0.13c | Clinical characteristics | | | | PED (n) | 11 | 8 | >0.99b | Double layer sign (n) | 7 | 9 | 0.28b | Ellipsoid integrity | 19 | 3 | 0.001b | ELM integrity | 16 | 12 | >0.99b | Hyperreflective foci in the OS and ON layers | 17 | 15 | 0.43b | Subretinal deposits | 8 | 10 | 0.28b | Baseline SFCT | 497.50 ± 99.36 | 365.50 ± 119.04 | 0.002a | Baseline CCD (%) | 6.71 ± 4.23 | 6.33 ± 3.83 | 0.80a | Baseline Sattler + Haller density (%) | 6.21 ± 3.56 | 5.36 ± 2.47 | 0.64c | Abnormal choroidal vessels of choriocapillaris in OCTA | 9 | 8 | >0.99b |
|
|
CSC, central serous chorioretinopathy; BCVA, best-corrected visual acuity; PED, pigment epithelial detachment; ELM, external limiting membrane; OS, outer segment; ON layer, outer nuclear layer; DD, disc diameter; SFCT, subfoveal choroidal thickness; CCD, choriocapillaris density; OCTA, optical coherence tomography angiography. aIndependent sample Student’s t-test. bFisher’s exact test. cWilcoxon signed-rank sum test.
|