Antibacterial and Antioxidant Efficacies of Secondary Metabolites from the Roots of Cyphostemma adenocaule: A Combined In Vitro and In Silico Study

Table 9

ADME predictions of the isolated compounds (1–6) generated by SwissADME computing tool.

Compound no.	LogKp (cm/s)	GIA	BBB	Inhibitor interaction
				P-gp substrate	CYP1A2	CYP2C19	CYP2C9	CYP2D6	CYP3A4
1	−2.20	Low	No	No	No	No	No	No	No
2	−5.23	High	Yes	No	No	No	Yes	No	No
3	−5.24	High	No	No	No	No	Yes	No	No
4	−7.40	Low	No	No	Yes	No	No	No	Yes
5	−6.14	Low	No	No	No	No	No	No	Yes
6	−5.60	Low	No	No	No	No	No	No	No
Ciprofloxacin	−9.09	High	No	Yes	No	No	No	No	No

BBB, blood-brain barrier; CYP, cytochrome-P; GIA, gastrointestinal absorption; LogKp, skin permeation value; P-gp, P glycoprotein.