Molecular Evolution of Interferon-Epsilon (IFNε) Pseudogene Modulates Innate and Specific Antiviral Immunity in Manis javanica

Figure 4

Alignment of IFN-protein sequences from various clades were used to determine evolutionary rate clusters based on structure. This is done using a genetic algorithm (GA) model. Maximum-likelihood labeling was used to classify each cluster, and GA then determines the clustering efficiency. Edges (rate) were labeled with the GA model’s average rate prediction, and nodes (residues) were interpreted according to their Steinfeld class and biochemical features.