Inhibition of Peptidyl Arginine Deiminase-4 Prevents Renal Ischemia-Reperfusion-Induced Remote Lung Injury

<div>Neutrophil extracellular traps (NETs) in the mouse lung following renal IR-induced pulmonary injury. (a) Representative confocal images of NETs demonstrated colocalization of NE and CitH3 with diffuse DAPI staining nuclei. NETs: neutrophil extracellular traps; CitH3: citrullinated histone H3 (scale bar: 10 <i>μ</i>m). (b) Quantification of NETs in pulmonary sections from different groups. (c) Quantification of DNA/MPO levels in bronchoalveolar lavage fluid (BALF). 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Mediators of Inflammation

fig4

Figure 4

Figure 4: Inhibition of Peptidyl Arginine Deiminase-4 Prevents Renal Ischemia-Reperfusion-Induced Remote Lung Injury 