Oxidative and/or Inflammatory Thrust Induced by Silver Nanoparticles in Rabbits: Effect of Vitamin E or NSAID Administration on Semen Parameters

Table 3

Estimated marginal means and standard error of principal component (PC) scores in rabbits treated with AgNPs (AgNP group), with AgNPs and an anti-inflammatory (AgNPs + NSAID group) or with AgNPs and vitamin E (AgNPs + Vit E group).

PC	Group^1			value
	AgNPs	AgNPs + NSAID	AgNPs + Vit E
				Group	Time	Interaction
Motility				<0.001	<0.001	<0.001
Volume				<0.001	0.401	<0.001
Antioxidants				<0.001	<0.001	<0.001
Oxidative metabolites				0.548	<0.001	<0.001
Redox reaction				<0.001	<0.001	<0.001
TNF-α and IL-8				<0.001	<0.001	<0.001
IL-6				<0.001	<0.001	<0.001

Values in the same row not sharing the same subscript are significantly different at (Sidak correction).¹AgNP group, treated with 5 mM AgNP solution; AgNPs + NSAID group, treated with 0.2 mg/kg b.w of anti-inflammatory and 5 mM AgNP solution. AgNPs + Vit E group, treated with 0.18 mg/kg b.w. of α-tocopheryl acetate and 5 mM AgNP solution.