Aqueous Humor Apolipoprotein Concentration and Severity of Diabetic Retinopathy in Type 2 Diabetes

Figure 1

Representative images of two patients with mild NPDR and advanced NPDR: (a) Fluorescence angiography showing discrete changes with single microaneurysms in the macular area and (b) optical coherence tomography image (OCT) of the same patient showing intra- and subretinal fluid leaking from the aneurismatic vessels. The white square in (a) marks the magnified area presented in the upper right corner showing the microaneurysms. (c) Fluorescence angiography and (d) OCT of a patient with advanced NPDR. The red circles in (a) and (c) mark the most prominent of the multiple, throughout the retina scattered microaneurysms. The yellow asterisks in (c) mark areas of ischemia. Corresponding to the central retinal changes visible in the angiography frame, the OCT shows intraretinal fluid and hyperreflective foci probably resembling the leakage of lipids and protein into the retinal tissue.