Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis

<div>The biological effect of AYC and MCC950 on inflammasome- and pyroptosis-related molecules. (a, b) Western blotting results showing the protein levels of NLRP3, ASC, cleaved caspase-1, IL-1<i>β</i>, and GSDMD among the sham, OA, and AYC groups. (a, c) Levels of the above proteins among the sham, OA, and MCC950 groups. (d, e) TUNEL assay indicated that positive nuclei were increased markedly in the OA synovial tissue compared with the sham-treated group. Positive cells were reduced in the Ac-YVAD-cmk and MCC950 groups. 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Mediators of Inflammation

fig3

Figure 3

Figure 3: Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis 