Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis

<div>LPS+ATP-treated macrophages. (a) Altered morphology of THP-1 cells under PMA stimulation. 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(b, c) Western blotting results of NLRP3, ASC, cleaved caspase-1, IL-1<i>β</i>, and GSDMD changes on protein levels in LPS-treated macrophages. (d) The results of qRT-PCR showed changes on mRNA levels among the control, LPS+ATP, LPS+ATP+MCC950, and LPS+ATP+AYC groups. 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Mediators of Inflammation

fig4

Figure 4

Figure 4: Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis 