Review Article
Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling
Table 1
Posttranslational modifications of ezrin protein.
| Phosphorylation site | Kinases/phosphorylation factors | Biological effects | References |
| Serine-66 | Protein kinase A (PKA) | Mediate the remodeling of the apical membrane cytoskeleton | [64] | Tyrosine-145, 146 | Src | Participate in cell proliferation, adhesion, and migration | [56, 57] | Tyrosine-190 | Src Homology-2 (SH2) | A docking point, the premise for phosphorylation of Tyrosine-145 | [24] | Threonine-235 | Cyclin-dependent kinase 5 (CDK5) | Cooperates with Threonine-576 | [23, 55] | Tyrosine-270 | — | Affect the FERM-membrane interaction | [30] | Tyrosine-291 | — | Weaken the FERM and C-terminal interaction | [30] | Tyrosine-353 | Phosphoinositide 3-kinase (PI3-kinase) PI3-kinase/Akt pathway | Participate in the reorganization of the actin cytoskeleton | [58–60] | Tyrosine-354 | — | Link to mobility and cellular adhesion | [57, 61] | Tyrosine-477 | Src, epidermal growth factor (EGF) | Promotes the cell diffusion | [62, 63] | Serine-535, 536 | Bach2 | Weaken the FERM and C-terminal interaction | [30, 65] | Threonine-567 | Phosphatidylinositol 4,5-bisphosphate (PIP2) Nck-interacting kinase (NIK) G protein-coupled receptor kinase 2 (GRK2) | Uncoupling of FERM and C-terminal domains | [51–53] | Arginine579 Glu244 | — | Form a tight salt bridge | [30] |
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