Integrative Analysis of Clinical and Bioinformatics Databases to Reveal the Role of Peripheral Innate Immunity in Kawasaki Disease

Figure 3

Analysis of myeloid cell subsets. (a) Cell types identified in myeloid cells using UMAP. (b) Volcano plot of DEGs (|logFC| ≥ 0.25 and adjusted ). The top 20 DEGs are marked. (c) Expression of four major DEGs in myeloid cells. The dot size represents the percent expressed, and the color scale represents the average expression. The DEGs were mainly expressed in CD14⁺CD16⁺ monocytes. (d) Pseudo-time analysis of monocyte subsets in KD, using Monocle. The developmental trajectory began with CD14⁻CD16⁺ monocytes and ended with CD14⁺CD16⁺ monocytes; inflammatory gene expression increased during development.

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