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Regulation manners | Cell types | Stimulus (bacterium or bacterial PAMPs) | Suppression or induction of Inflammation | Reference |
Pro-inflammatory molecules | Anti-inflammatory molecules |
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↑Wnt3a addition | Murine macrophages | M. tuberculosis | TNF↓ | — | [12] |
↑Wnt3a addition | Murine macrophages | M. bovis BCG | TNFα↓ IL-6↓ | — | [13] |
↑Wnt3a addition | Murine alveolar macrophages | P. aeruginosa | IL-1β↓ TNFα↓ MIP-2↓ | — | [14] |
↑Wnt6 addition | Murine macrophages | M. tuberculosis | TNFα↓ | Arg-1↑ MRC-1↑ | [16] |
↓Wnt6 knockdown | Murine macrophages | M. tuberculosis | TNFα↑ | Arg-1↓ MRC-1↓ | [16] |
↓Wnt3a Inhibition | Human monocyte cells | LPS | IL-6↑ IL-12p40↑ TNFα↑ | — | [3] |
↑Wnt activation | Human umbilical vein endothelial cells | Heat-inactivated Rickettsia conorii | IL-6↓ IL-8↓ CXCL1↓ | — | [18] |
↓Wnt inhibition | Human cancer cell lines | LPS | IL-1β↑ | — | [19] |
↑Wnt2 overexpression | Mouse intestinal epithelial cells | Salmonella | IL-8↓ | — | [20] |
↑Wnt11 overexpression | Rat small intestinal epithelial cells | Salmonella | IL-8↓ | — | [21] |
↓Wnt1 knockdown | Human colonic epithelial cells | Salmonella | IL-6↑ IL-8↑ GM-CSF↑ | — | [26] |
↓GSK3β inhibition | Murine macrophages | M. avium | TNFα↓ | — | [12] |
↓GSK3β inhibition | Murine peritoneal macrophages | F. tularensis | TNFα↓ IL-6↓ IL-12p40↓ | IL-10↑ | [27] |
↓GSK3β knockdown | Murine peritoneal macrophages | F. tularensis | TNFα↓ | IL-10↑ | [27] |
↓GSK3β inhibition | Human monocytes | LPS | TNFα↓ IL-6↓ IL-12p40↓ | IL-10↑ | [28] |
↓GSK3β inhibition | Hamster kidney cells | Avian infectious bronchitis virus (IBV) | TNFα↓ IL-1β↓ | — | [29] |
↓GSK3β inhibition | Chicken embryonic fibroblast cells | Marek’s disease virus (MDV) | IL-1β↓ | — | [30] |
↓GSK3β inhibition | Monkey embryonic kidney epithelial cells | Porcine reproductive and respiratory syndrome virus (PPRSV) | TNFα↓ IL-1β↓ IL-6↓ IL-8↓ | — | [31] |
↓GSK3β knockdown | Murine microglia | LPS | — | IL-10↑ | [32] |
↓GSK3β inhibition | Mouse microglia | Heat-inactivated S. aureus | TNFα↓ | IL-10↑ | [33] |
↓GSK3β inhibition and knockdown | Primary murine microglia | LPS | TNFα↓ | — | [34] |
↓GSK3β inhibition | Colonic epithelial cells | Salmonella typhimurium | IL-8↓ | — | [35] |
↓GSK3β inhibition and knockdown | Primary astrocytes | LPS | IL-6↓ | — | [36] |
↓GSK3β inhibition | Primary microglia | LPS | IL-6↓ | — | [36] |
↑GSK3β overexpression | Primary astrocytes | LPS | IL-6↑ | — | [36] |
↑β-catenin overexpression | Mouse bone marrow-derived neutrophils | P. aeruginosa | IL-6↓ TNFα↓ MIP-2↓ | — | [37] |
↑β-catenin overexpression | Murine macrophages | P. aeruginosa | IL-1β↓ IL-6↓ TNFα↓ MIP-2↓ | — | [37] |
↑β-catenin overexpression | Human alveolar type II epithelial cells | M. bovis BCG or LPS | IL-1α↓ IL-2↓ IL-6↓ IL-8↓ TNFα↓ | — | [40] |
↓β-catenin knockdown | Murine macrophages | LPS | IL-6↑ | — | [42] |
↑β-catenin overexpression | Human intestinal epithelial cells | Salmonella | IL-8↓ | — | [41] |
↓β-catenin knockdown | human monocytes | LPS | IL-6↑ IL-12p40↑ TNFα↑ | — | [3] |
↓β-catenin inhibition | Chicken embryonic fibroblast cells | Marek’s disease virus (MDV) | IFNβ↑ IL-8↑ | — | [30] |
↓β-catenin knockdown | Mouse bone marrow-derived DCs | LPS | IL-6↑ IL-12p40↑ TNFα↑ CXCL-10↑ | — | [44] |
↓β-catenin inhibition | Porcine kidney cells and new-born pig trachea cells | Helicobacter pylori | IL-8↑ CCL4↑ CCL5↑ | — | [43] |
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