Evaluation of Intraperitoneal [¹⁸F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity

Figure 2

Effect of varying and on and values and intersample variability following i.p. radiotracer administration. (a, b) Values calculated from TACs following i.p. radiotracer administration () by the extended Patlak analysis for (a) and (b) with variable (-axis) and (60 min: red triangles; 90 min: blue open squares; and 120 min: black circles). Values are (c, d) %CV for (c) and (d) with variable and . (e–h) As (a–d) but showing the effect of varying (-axis) on (e) and (f) outcome values and S.D. as well as %CV for (g) and (h) using a of 120 min (black circles) or 140 min (green squares).

(a)

(b)

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(e)

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(h)