[18F]-(2S,4R)4-Fluoroglutamine PET Imaging of Glutamine Metabolism in Murine Models of Hepatocellular Carcinoma (HCC)
Table 1
Relative expression for major glutamine influx transporters and catabolism enzymes in the normal liver, MYC HCC, and MET HCC tissues based on the microarray studies.
Gene name
Average Log2 expression
Normal liver
MYC HCC
MET HCC
Glutamine influx transporters
SLC1A5
6.09
8.40 ()
7.18 ()
SLC6A14
4.93
4.75
4.70
SLC6A19
5.35
5.80
5.50
SLC7A5
6.68
8.75 ()
8.20 ()
SLC7A6
6.32
8.55 ()
6.37
SLC7A7
7.20
8.23 ()
8.38 ()
SLC38A1
5.13
5.20
4.79
SLC38A2
9.61
9.78
9.67
SLC38A5
6.44
6.20
6.29
SLC38A7
6.94
6.82
7.15
SLC38A8
6.13
6.10
6.19
Glu catabolism emzymes
Gls
5.81
9.07 ()
6.08
Gls2
8.42
7.73 ()
6.32 ()
Glul
9.75
8.39 ()
11.9 ()
. Bold: upregulated in HCC. Italic: downregulated in HCC.