Research Article

[18F]-(2S,4R)4-Fluoroglutamine PET Imaging of Glutamine Metabolism in Murine Models of Hepatocellular Carcinoma (HCC)

Table 1

Relative expression for major glutamine influx transporters and catabolism enzymes in the normal liver, MYC HCC, and MET HCC tissues based on the microarray studies.

Gene nameAverage Log2 expression
Normal liverMYC HCCMET HCC

Glutamine influx transportersSLC1A56.098.40 ()7.18 ()
SLC6A144.934.754.70
SLC6A195.355.805.50
SLC7A56.688.75 ()8.20 ()
SLC7A66.328.55 ()6.37
SLC7A77.208.23 ()8.38 ()
SLC38A15.135.204.79
SLC38A29.619.789.67
SLC38A56.446.206.29
SLC38A76.946.827.15
SLC38A86.136.106.19

Glu catabolism emzymesGls5.819.07 ()6.08
Gls28.427.73 ()6.32 ()
Glul9.758.39 ()11.9 ()

. Bold: upregulated in HCC. Italic: downregulated in HCC.