Research Article
Preclinical Evaluation of an Activity-Based Probe for Intraoperative Imaging of Esophageal Cancer
Figure 5
VGT-309 labels esophageal cancer allografts and xenografts. (a). Representative bright field, near-infrared (NIR) and overlay images of mice bearing various esophageal cancer flank tumors (/cell line) 24 hours after injection of 2 mg/kg VGT-309. Mice bearing KB flank xenografts () pretreated with 50 mg/kg JPM-OEt via intraperitoneal injection for 5 days before VGT-309 administration served as a negative control and those pretreated with delivery vehicle () served as a positive control. (b). Mean fluorescent intensity (MFI) of tumor and background tissue with symbol color indicating cell line. (c). Signal-to-background ratios (SBRs) from the flank tumors. Each point represents a single tumor with means and error bars displayed for each group.
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