Research Article

Immuno-PET Imaging of Siglec-15 Using the Zirconium-89-Labeled Therapeutic Antibody, NC318

Figure 2

(a) Representative plot from an in vitro [89Zr]Zr-DFO-NC318 saturation binding assay using 624-MEL+S15 cells with each point representing the average of duplicates; for this plot:  nM,  nM ( sites/cell); () determined in the presence of 10-6 M NC318; . (b) Siglec-15 concentrations (, sites per cell) in 624-MEL+S15, LOX IMIV, HCC-827, and 624-MEL WT cancer cell lines determined from in vitro saturation binding assays; each bar represents the ( (624-MEL+S15), (LOX IMIV), and (624-MEL WT and HCC-827)).
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