Research Article
Immuno-PET Imaging of Siglec-15 Using the Zirconium-89-Labeled Therapeutic Antibody, NC318
Figure 3
(a) Representative plot from an in vitro [89Zr]Zr-DFO-NC318 competition-binding assay using NC318 (self-displacement (Morris method)) with 624-MEL+S15 cells. Each point (average of duplicates) represents % specific bound ( nM). (b) Representative plot for the determination of the immunoreactivity fraction (% immunoreactivity) of [89Zr]Zr-DFO-NC318 (same batch) using the Morris method (for this plot: linear regression curve fit, , ; % ).
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