Immuno-PET Imaging of Siglec-15 Using the Zirconium-89-Labeled Therapeutic Antibody, NC318

Table 1

[⁸⁹Zr]Zr-DFO-NC318 human dosimetry extrapolated from Balb/c mouse biodistributions (includes the organs used in the kinetics input form of OLINDA, the mouse residence times, the extrapolated human residence times, and the dose the tissue received per unit injected activity).

Organ	Mouse residence time (h)	Human residence time (h)	Dose (mSv/MBq)	Dose (rem/mCi)
Adrenals	0.409	0.0170	0.305	1.13
Brain	0.0577	0.0540	0.181	0.669
Breasts	NA	NA	0.0897	0.332
Gallbladder wall	NA	NA	0.153	0.567
LLI wall	NA	NA	0.159	0.588
Small intestine	2.64	0.391	0.154	0.571
Stomach wall	0.189	0.0237	0.119	0.440
ULI wall	NA	NA	0.144	0.534
Heart wall	0.142	0.121	0.150	0.555
Kidneys	0.930	1.24	0.562	2.08
Liver	3.50	1.78	0.253	0.936
Lungs	0.854	1.01	0.218	0.808
Muscle	NA	NA	0.147	0.542
Ovaries	0.0475	0.010	0.135	0.500
Pancreas	0.0885	0.021	0.185	0.685
Red marrow	NA	NA	0.868	3.21
Osteogenic cells	NA	NA	1.53	5.67
Trabecular bone	15.0	40.80	NA	NA
Skin	NA	NA	0.109	0.402
Spleen	0.386	0.256	0.278	1.03
Testes	NA	NA	0.092	0.340
Thymus	0.0845	0.00736	0.136	0.502
Thyroid	0.0321	0.0180	0.202	0.748
Urinary bladder wall	0.0403	0.0298	0.101	0.372
Uterus	NA	NA	0.114	0.423