Targeted Imaging of Endometriosis and Image-Guided Resection of Lesions Using Gonadotropin-Releasing Hormone Analogue-Modified Indocyanine Green

<div>GnRHa-ICG targets endometriotic lesions. (a) Representative GFP and NIRF images of the pelvic and peritoneal cavity 2 h after injection of GnRHa-ICG, ICG, and NaCl in GFP mouse models for endometriosis. Yellow dotted lines indicate the EMT locations. (b) Ex vivo near-infrared fluorescence images of the EMTs and mouse organs 2 h after intraperitoneal injection of GnRHa-ICG, ICG, and NaCl. (c) Histopathological analysis of an EMT slice showing the colocalization of endometriotic cells, GnRHR expression, and GnRHa-ICG fluorescence. Scale bar, 250 <i>μ</i>m. (d) Comparison of fluorescence intensities between EMT, muscle, and intestine.</div>

Molecular Imaging

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Figure 3: Targeted Imaging of Endometriosis and Image-Guided Resection of Lesions Using Gonadotropin-Releasing Hormone Analogue-Modified Indocyanine Green 

Figure 3 | Targeted Imaging of Endometriosis and Image-Guided Resection of Lesions Using Gonadotropin-Releasing Hormone Analogue-Modified Indocyanine Green 