Research Article

Targeted Imaging of Endometriosis and Image-Guided Resection of Lesions Using Gonadotropin-Releasing Hormone Analogue-Modified Indocyanine Green

Figure 4

Targeted recognition capacity of GnRHa-ICG. (a) Comparison of recognition capacity to the EMTs between visible-guided surgery and NIRF-guided surgery. After visible surgical resection, no visible lesions were observed, but there were remaining hidden lesions removed under the guidance of NIRF. Yellow arrows indicate the EMT locations. (b) The tissues resected with NIRF-guided surgery were confirmed to be endometriotic tissues by histopathology. (c) Comparing the maximum diameters of the EMTs resected by imaging-guided surgery (red circles) and visible-guided surgery (blue circles) (37 vs 28 biopsies, mice), and the median size is and  mm, respectively (). (d) The recognition accuracy of GnRHa-ICG indicates that the probe can identify the lesions as small as 1 mm in diameter.
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