First-in-Human PET Imaging of [¹⁸F]SDM-4MP3: A Cautionary Tale

Figure 5

Preclinical comparison of [¹⁸F]SDM-4MP3 and [¹⁸F]SynVesT-1 in rats. (a) Whole-brain time activity curves from 0-120 min postinjection. Blocking study data from [¹⁸F]SynVesT-1 was acquired 15 min following injection of 30 mg/kg levetiracetam, summed 120 min images showing uptake of (b) [¹⁸F]SDM-4MP3, (c) [¹⁸F]SynVesT-1, and (d) [¹⁸F]SynVesT-1 under levetiracetam blocking condition.