Research Article
First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale
Figure 8
(a) Simplified synthesis route of the precursors by Yale and PharmaSynth and radiosynthesis of [18F]SynVesT-1 ([18F]SDM-8). Nitrogen in pyridinyl ring is shown in blue. (b) Simplified synthesis route of the precursor by ABX and radiosynthesis of [18F]SDM-4MP3. Differentiating pyridinyl nitrogen is shown in green. Reaction conditions for radiosynthesis: Cu(OTf)2, pyridine, [18F]KF, DMAc, 110°C, 20 min.
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