The Effectiveness of Physiotherapy Interventions for Mobility in Severe Multiple Sclerosis: A Systematic Review and Meta-Analysis

Table 1

PICO describing inclusion criteria/exclusion criteria.

Study component	Inclusion criteria	Exclusion criteria
Population	(1) Diagnosed with Multiple Sclerosis according to McDonald criteria; (2) Adults (>18 years old); (3) Severe mobility disability (reported EDSS or narrative description of mobility disability E.G. use of walking aid)	(1) Not MS patients; (2) Paediatric participant (<18 years old); (3) Mild-moderate mobility disability ()
Intervention	(1) Physical therapy intervention	(1) Study group includes physiotherapy intervention and concomitant drug or other intervention; (2) Study group includes more than one type of physiotherapy
Comparism	No intervention or sham
Outcomes	Paper reports mobility-related endpoints or outcome	Study reports only nonmobility-related outcomes