Fine-Tuning Reception in the Bone: PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>γ</mml:mi></mml:math> and Company

Floyd, Z. Elizabeth; Zvonic, Sanjin; Nuttall, Mark E.; Gimble, Jeffrey M.

doi:https://doi.org/10.1155/PPAR/2006/52950

PPAR Research

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PPARs and Bone Metabolism

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Review Article | Open Access

Volume 2006 | Article ID 052950 | https://doi.org/10.1155/PPAR/2006/52950

Fine-Tuning Reception in the Bone: PPARγ and Company

Z. Elizabeth Floyd,¹Sanjin Zvonic,¹Mark E. Nuttall,²and Jeffrey M. Gimble¹

Received29 Mar 2006

Revised19 Jun 2006

Accepted26 Jun 2006

Published30 Jul 2006

Abstract

PPARγ plays a central role in the formation of fat. Regulation of PPARγ activity depends on numerous factors ranging from dietary ligands to nuclear hormone coactivators and corepressors to oxygen-sensing mechanisms. In addition, the interplay of PPARγ with other nuclear hormone receptors has implications for the balance between adipogenesis and osteogenesis in mesenchymal stem cells of the bone marrow stroma. This review will explore a range of factors influencing PPARγ activity and how these interactions may affect osteogenesis.

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Copyright © 2006 Z. Elizabeth Floyd et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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