Research Article

Progressive Improvement in 5-Year Survival Rates for Extremity Soft Tissue Sarcomas from 1999 to 2019

Table 1

Patient demographics and clinical characteristics stratified by time period.

N = 5,654
1999–2005 (n = 1,393) n (%)2006–2012 (n = 2,074) n (%)2013–2019 (n = 2,187) n (%)

Demographics
Sex
 Male771 (55.3)1,155 (55.7)1,190 (54.5)0.689
 Female622 (44.7)919 (44.3)997 (45.5)
Age group (years)
 <30111 (8.0)147 (7.1)161 (7.4)<0.001
 30–59684 (49.1)957 (46.1)892 (40.8)
 ≥60598 (42.9)970 (46.8)1,134 (51.9)
Race
 Caucasian1,088 (78.1)1,597 (77.0)1,648 (75.4)0.028
 African American135 (9.7)195 (9.4)202 (9.2)
 Other162 (11.6)276 (13.3)314 (14.3)
 Unknown8 (0.6)7 (0.3)23 (1.1)
Ethnicity
 Non-Hispanic1,188 (85.3)1,732 (83.5)1,794 (82.0)0.038
 Hispanic205 (14.7)342 (16.5)393 (18.0)
 Marital status
 Married792 (56.9)1,167 (56.3)1,247 (57.0)0.130
 Single283 (20.3)440 (21.2)487 (22.2)
 Other279 (20.0)381 (18.4)374 (17.1)
 Unknown39 (2.8)86 (4.1)79 (3.6)

Tumor characteristics
Primary site
 Upper extremity343 (24.6)487 (23.5)521 (23.8)0.738
 Lower extremity1,050 (75.4)1,587 (76.5)1,666 (76.2)
Tumor size (cm)
 <5442 (31.7)630 (30.4)630 (28.8)0.350
 5–10434 (31.2)631 (30.4)694 (31.7)
 >10517 (37.1)813 (39.2)863 (39.5)
Grade
 I243 (17.4)434 (20.9)453 (20.7)0.023
 II334 (24.0)422 (20.3)473 (21.6)
 III816 (58.6)1,218 (58.7)1,261 (57.7)
Metastasis
 No990 (71.1)1,512 (72.9)1,902 (87.0)<0.001
 Yes403 (28.9)562 (27.1)285 (13.0)
Histology
 Fibromatous452 (32.4)475 (22.9)365 (16.7)<0.001
 Myxomatous37 (2.7)49 (2.4)57 (2.6)
 Lipomatous412 (29.6)609 (29.4)599 (27.4)
 Myomatous180 (12.9)269 (13.0)276 (12.6)
 Synovial97 (7.0)122 (5.9)103 (4.7)
 NOS74 (5.3)151 (7.3)107 (4.9)
 All other types141 (10.1)399 (19.2)680 (31.1)

Treatment
Surgery
 No53 (3.8)98 (4.7)156 (7.1)<0.001
 Yes1,340 (96.2)1,976 (95.3)2,031 (92.9)
Radiation
 No/unknown577 (41.4)900 (43.4)959 (43.9)0.337
 Yes816 (58.6)1,174 (56.6)1,228 (56.1)
Chemotherapy
 No/Unknown1,112 (79.8)1,602 (77.2)1,784 (81.6)0.002
 Yes281 (20.2)472 (22.8)403 (18.4)

NOS, not otherwise specified.