Exploring the Diagnostic Dilemma of Indeterminate Pulmonary Nodules in Patients with Primary Sarcoma of Bone
Table 2
Patients presenting with primary sarcoma of bone without evident metastatic disease on initial staging but with indeterminant nodules on CT scan of the chest: descriptive data of patients; the subgroups that did and did not develop metastatic disease, along with comparison between the groups that developed metastatic disease vs. those that did not.
All patients presenting with indeterminant nodules on initial CT chest scan
Patients who progressed to metastatic disease
Patients who did not progress to metastatic disease
value
N
73
30
43
Age (years)
50 (19–81)
50.9 (19–81)
49.5 (24–79)
0.814
Follow-up (months)
40.9 (2–192)
22.9 (2–78)
53.7 (8–192)
<0.001
Gender
Male
41 (56.2%)
16 (53.3%)
25 (58.1%)
0.684
Female
32 (43.8%)
14 (46.7%)
18 (41.9%)
Smoking history
Never
42 (57.5%)
17 (56.7%)
25 (58.1%)
0.898
+Smoking history
25 (34.2%)
10 (33.3%)
15 (34.9%)
Unknown
6 (8.2%)
3 (10.0%)
3 (7.0%)
Diagnosis
Osteosarcoma
24 (32.9%)
9 (30.0%)
15 (34.9%)
0.637
Chondrosarcoma
30 (41.1%)
12 (40.0%)
18 (41.9%)
Ewing sarcoma
4 (5.5%)
2 (6.7%)
2 (4.7%)
Chordoma
2 (2.7%)
0 (0%)
2 (4.7%)
Others
13 (17.8%)
7 (23.3%)
6 (14.0%)
Grade
Low
5 (6.8%)
1 (3.3%)
4 (9.3%)
0.321
High
68 (93.2%)
29 (96.7%)
39 (90.7%)
Anatomic location
Upper extremity
10 (13.7%)
3 (10.0%)
7 (16.3%)
0.805
Lower extremity
32 (43.8%)
13 (43.3%)
19 (44.2%)
Spine/chest wall
8 (11.0%)
3 (10.0%)
5 (11.6%)
Pelvis
23 (31.5%)
11 (36.7%)
12 (27.9%)
Size of the largest indeterminant nodule
1–5 mm
57 (78.1%)
22 (73.3%)
35 (81.4%)
0.615
6–9 mm
11 (15.1%)
6 (20.0%)
5 (11.6%)
10+ mm
5 (6.8%)
2 (6.7%)
3 (7.0%)
Number of nodules
1
20 (27.4%)
7 (23.3%)
13 (30.2%)
0.712
2
21 (28.8%)
8 (26.7%)
13 (30.2%)
3
18 (24.7%)
8 (26.7%)
10 (23.3%)
4
6 (8.2%)
4 (13.3%)
2 (4.7%)
5+
8 (11.0%)
3 (10.0%)
5 (11.6%)
value: comparison of patients presenting with indeterminant nodules who went on to develop metastatic disease vs. those who did not develop metastatic disease, performed with Chi-square and Mann–Whitney U tests.
