Focus on Mesenchymal Stem Cell-Derived Exosomes: Opportunities and Challenges in Cell-Free Therapy
Table 3
Clinical trials of exosome–based therapies.
Study title
Disease
Intervention
Phase
NCT
Effect of plasma-derived exosomes on intractable cutaneous wound healing: prospective trial
Ulcer
Autologous exosomes Rich plasma
Early phase 1
NCT02565264
Study investigating the ability of plant exosomes to deliver curcumin to normal and colon cancer tissue
Colon cancer
Curcumin delivery by exosomes
Phase 1
NCT01294072
Effect of microvesicles and exosomes therapy on β-cell mass in type I diabetes mellitus (T1DM)
Type I diabetes mellitus
Umbilical cord blood-derived MSC microvesicles
Phase 2 Phase 3
NCT02138331
Preliminary clinical trial investigating the ability of plant exosomes to abrogate oral mucositis induced by combined chemotherapy and radiation in head and neck cancer patients
Phase II trial of a vaccination with tumor antigen-loaded dendritic cell-derived exosomes on patients with unresectable non-small-cell lung cancer responding to induction chemotherapy