Hypoxia-Preconditioned Wharton’s Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System

<div>Immunocytochemistry of Bcl-2, Bax, and active caspase-3 in human islets cocultured with WJ-MSCs. The significant enhancement of Bcl-2 and reduction of Bax and active caspase-3 protein levels in the cocultured islets with Hpc-MSCs and Nc-MSCs (yellow arrows show positive protein expression). Scale bar: 10 <i>μ</i>m. WJ-MSCs: Wharton’s jelly-derived mesenchymal stem cells; Nc-MSCs: normoxia condition MSCs; Hpc-MSCs: hypoxia preconditioning MSCs; D: direct coculture; I: indirect coculture.</div>

Stem Cells International

fig4

Figure 4

Figure 4: Hypoxia-Preconditioned Wharton’s Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System 

Figure 4 | Hypoxia-Preconditioned Wharton’s Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System 