Molecular Modulation of Fetal Liver Hematopoietic Stem Cell Mobilization into Fetal Bone Marrow in Mice

Figure 1

Microenvironment in the fetal liver is crucial for HSC proliferation. SCF ⁺ DLK ⁺ cells secret Angptl2, Angptl3, IGF2, and TPO to accelerate HSC proliferation in the fetal liver. Nestin⁺NG2⁺ pericytes associated with portal vessels is a fetal liver niche, supporting HSC expansion. Fetal liver endothelial cell produces SDF-1α favoring HSC mobilization. Loss of ATF4 in the fetal liver niche reduces HSC expansion through decreasing Angptl3, IGF2, and VEGFA.