Molecular Modulation of Fetal Liver Hematopoietic Stem Cell Mobilization into Fetal Bone Marrow in Mice

Figure 5

WAVE2 complex regulates fetal liver HSC mobilization into the bone marrow by modulating c-Abl signaling. Loss of Hem1 leads to degradation of WAVE2 complex without affecting actin polymerization in fetal liver HSCs. Lodgment of fetal liver HSCs into the bone marrow is impaired under Hem1 mutation, which is related to inhibiting c-Abl signaling pathway activation with decreasing phosphorylated CrkL (pCrkL).