Human Umbilical Cord Mesenchymal Stem Cells Attenuate Severe Burn-Induced Multiple Organ Injury via Potentiating IGF-1 and BCL-2/BAX Pathway

Table 1

The hUCMSC administrations significantly improved parameters of the heart, liver, and kidney functions. Serological biochemical analysis showed that high sensitive parameters of myocardial damage, such as troponin, CK, and CK-MB levels in the burn groups, were explicitly increased than those in the sham groups, and they were significantly decreased by hUCMSC administrations. The levels of liver function parameters ALT, AST, and LDH and kidney function parameters urea and creatinine in the burn groups were markedly higher than those in the sham groups, and their levels in the burn+hUCMSC groups were significantly lower than those in the burn groups.

	Sham	Burn	Burn+hUCMSCs
Troponin (pg/mL)		^@@
CK (U/L)		^@@
CK-MB (U/L)		^@@
LDH (U/L)		^@@
ALT (U/L)		^@@
AST (U/L)		^@@
Urea (mmol/L)		^@@
Creatinine (μmol/L)		^@@

^@ and ^@@ compared with the sham group, respectively. ^∗ and ^∗∗ compared with the burn group, respectively.