Long Noncoding RNA and mRNA m6A Modification Analyses of Periodontal Ligament Stem Cells from the Periodontitis Microenvironment Exposed to Static Mechanical Strain

Figure 6

METTL3 is differentially expressed in stained pPDLSCs and promotes the osteogenic differentiation of pPDLSCs. The relative expression level of METTL3 in hPDLSCs and pPDLSCs under strain (a). The effects of lentiviruses on METTL3 were determined by qPCR (b), western blotting (c) and quantification analysis (d). The expression levels of osteogenesis-related genes (ALP, RUNX2, and OCN) after 7 days of osteogenic induction (e). Alizarin Red staining and quantification analysis after 21 days of osteogenic induction (f and g). OE, overexpression. , ,  ns .

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