Normothermic Ex Vivo Heart Perfusion with Mesenchymal Stem Cell-Derived Conditioned Medium Improves Myocardial Tissue Protection in Rat Donation after Circulatory Death Hearts

Table 1

Bioactive factor detected in CM from BMSCs.

Phenomena	Specific properties	Factors
Inflammatory	Proinflammatory	CINC1/2/3, MCP1, TNF-α, TWEAK R
	Anti-inflammatory	IL-10, Decorin, Galectin-1
Stress	Oxidative stress	Decorin
Apoptosis	Antiapoptotic	TIMP1, Activin A, VEGF-A, Decorin
Others	Immunomodulator	LIX, IL-10
	Chemokines	Fractalkine
	Adhesion molecules	ICAM-1
	Proangiogenesis	MCP1, PDGF-AA, CINC1
		VEGF-A, Neuropilin-2
		TWEAK R, Notch-2
	Cell proliferation	TIMP1, β-NGF, Notch-2
	ECM modulation	TIMP1

CINC1/2/3: cytokine-induced neutrophil chemoattractant 1/2/3; MCP1: monocyte chemoattractant protein-1; TNF-α: tumor necrosis factor-α; TWEAK R: TNF-like weak inducer of apoptosis R; IL-10: interleukin-10; TIMP1: tissue inhibitor of metalloproteinase-1; VEGF-A: vascular endothelial growth factor-A; LIX: lipopolysaccharide-induced chemokine; ICAM-1: intercellular cell adhesion molecule-1; MCP-1: monocyte chemoattractant protein-1; PDGF-AA; platelet-derived growth factor-AA; β-NGF: β-nerve growth factor.