Electrophysiological Changes of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes during Acute Hypoxia and Reoxygenation

<div>Functionality of the hiPSC-CMs was evaluated via MEA measurements during baseline, hypoxia, and reoxygenation. (a) Normalized beating frequency (beats per minute, BPM) of hiPSC-CMs decreased during hypoxia and was restored during reoxygenation. (b) Corrected field potential duration (cFPD) did not change significantly during hypoxia or reoxygenation. (c) Depolarization time of the hiPSC-CMs increased during hypoxia and returned close to baseline during reoxygenation. (d) hiPSC-CM depolarization amplitude decreased significantly during hypoxia and recovered during reoxygenation. 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Stem Cells International

fig4

Figure 4

Figure 4: Electrophysiological Changes of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes during Acute Hypoxia and Reoxygenation 