Review Article

Advances and Challenges in Cancer Stem Cells for Onco-Therapeutics

Table 3

Ongoing clinical trials recruiting adenocarcinoma patients for CSC-based trials (source: clinicaltrials.gov; retrieved 20 May 2023).

Serial no.ConditionsInterventionsTrial number

1Gastric and cardia adenocarcinomasProcedure: biopsyNCT02491840

2Pancreas cancerDrug: bethanecholNCT03572283

3Resectable pancreatic adenocarcinomaDrug: HIPEC-gemcitabineNCT03251365

4Adenocarcinoma of lungGenetic: MSCTRAIL|Drug: placeboNCT03298763

5Pancreatic adenocarcinoma metastatic|BRCA1 mutation|BRCA2 mutation|Pancreatic acinar cell carcinoma|Pancreatic ductal adenocarcinoma|Pancreatic cancer|Metastatic pancreatic cancer|Metastatic pancreatic ductal adenocarcinoma|Breast cancer metastatic|Breast cancer stage IV|Pancreatic cancer stage IV|HER2-negative breast cancer|HER2 negative breast carcinoma|Adenocarcinoma of the breast|PALB2 gene mutationDrug: melphalan|Drug: BCNU|Drug: vitamin B12B|Drug: vitamin C|Drug: ethanol|Device: autologous hematopoietic stem cellsNCT04150042

6Fallopian tube clear cell adenocarcinoma|Fallopian tube endometrioid adenocarcinoma|Fallopian tube mucinous adenocarcinoma|Fallopian tube serous adenocarcinoma|Fallopian tube transitional cell carcinoma|Fallopian tube undifferentiated carcinoma|Malignant ovarian brenner tumor|Ovarian clear cell adenocarcinoma|Ovarian endometrioid adenocarcinoma|Ovarian mucinous adenocarcinoma|Ovarian seromucinous carcinoma|Ovarian serous adenocarcinoma|Ovarian transitional cell carcinoma|Ovarian undifferentiated carcinoma|Primary peritoneal serous adenocarcinoma|Recurrent fallopian tube carcinoma|Recurrent ovarian carcinoma|Recurrent primary peritoneal carcinomaOther: laboratory biomarker analysis|Procedure: mesenchymal stem cell transplantation|Biological: oncolytic measles virus encoding thyroidal sodium iodide symporterNCT02068794

7Pancreatic ductal adenocarcinoma|Metastatic pancreatic cancer|Circulating tumor cellOther: detection of circulating tumor cells expressing Axl: CTC-AXL(+)NCT05346536

8Pancreatic cancer|Metastatic pancreatic cancer|Metastatic pancreatic adenocarcinomaDrug: zolbetuximab|Drug: nab-paclitaxel|Drug: gemcitabineNCT03816163

9Colorectal cancer metastases and hepatocellular carcinomasProcedure: tumor /metastases removalNCT05384184

10Rectum adenocarcinomaOther: biopsyNCT02849158

11Central nervous system nongerminomatous germ cell tumor|Choriocarcinoma|Embryonal carcinoma|Immature teratoma|Malignant teratoma|Mixed germ cell tumor|Pineal region germ cell tumor|Pineal region immature teratoma|Pineal region yolk sac tumor|Suprasellar germ cell tumorDrug: carboplatin|Drug: etoposide|Biological: filgrastim|Drug: ifosfamide|Drug: mesna|Biological: pegfilgrastim|Procedure: peripheral blood stem cell transplantation|Other: questionnaire administration|Radiation: radiation therapy|Procedure: second-look surgery|Drug: thiotepaNCT04684368

12Hepatocellular carcinomaDrug: peginterferon α-2b (pegabin) with entecavir or tenofovir fumarate or propofol tenofovir fumarate | Procedure: radical surgeryNCT05466565