Umbilical Cord Mesenchymal Stem Cells Overexpressing Heme Oxygenase-1 Promotes Symptoms Recovery in Cystitis Rats by Alleviating Neuroinflammation

Figure 4

Transduced hUMSCs attenuates mechanical allodynia and comorbid behaviors via paracrine. (a) hUMSCs were labeled with Dil (red), and the fluorescent section showed that the cells failed to enter the spinal cord parenchyma, suggesting that hUMSCs treat inflammation through paracrine (bar = 200 μm). (b) Changes in the mechanical allodynia threshold after treatments (n = 10 per group). The data were analyzed by two-way ANOVA followed by the Tukey post hoc test. (c) Sucrose preference test (SPT) were performed on Day 21 (n = 8 per group). The data were analyzed by one-way ANOVA followed by the Tukey post hoc test. (d) Novel object recognition test (NORT) was performed on day 19 (n = 8 per group). The data were analyzed by one-way ANOVA followed by the Tukey post hoc test. , , and vs. the control group, and ^# and ^## vs. the CYP group. Error bars represent standard error of the mean (±SEM).

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