Review Article
Radiation Necrosis, Pseudoprogression, Pseudoresponse, and Tumor Recurrence: Imaging Challenges for the Evaluation of Treated Gliomas
Table 1
Cutoff values of PET tracers for the detection of glioma recurrence.
| Study | Modality | Tracer | Parameter | Cutoff | Sensitivity (%) | Specificity (%) |
| Deuschl et al. [32] | PET/MRI | 11C-methionine | Max T/N | 1.8 | 97.14 | 93.33 | Mean T/N | 1.3 | Tripathi et al. [33] | PET/CT | 11C-methionine | Max T/N | 1.9 | 95 | 89 | Terakawa et al. [34] | PET | 11C-methionine | Mean T/N | 1.58 | 75 | 75 | Herholz et al. [44] | PET | 11C-methionine | T/N | 1.47 | 76 | 87 | Garcia et al. [45] | PET | 11C-methionine | T/N | 2.35 | 90.5 | 100 | Takenaka et al. [46] | PET | 11C-methionine | T/N | 2.51 | 91.2 | 81.4 | Galldinks et al. [36] | PET | 18F-FET | Max T/N | 2.3 | 100 | 91 | Kebir et al. [37] | PET | 18F-FET | Max T/N | 1.9 | 84 | 86 | Jena et al. [43] | PET/MRI | 18F-FDG | Max T/N | 1.579 | 93.3 | 72.7 | Mean T/N | 1.179 | 90 | 81.8 | Enslow et al. [47] | PET | 18F-FDG | T/N | 1.83 | 100 | 75 | Max T/N | 6.2 | 90.9 | 75 |
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