Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model

Figure 4

In vivo dynamic [18F]-FDG PET-CT. (a) Dynamic [18F]-FDG PET-CT performed on tumor-bearing SCID mice receiving paclitaxel, D1143, or vehicle at D18 (1 week of treatment). Mean aorta SUV (left panel) and mean tumor SUV (right panel) have been measured every 5 seconds for 240 seconds. (b) Dynamic [18F]-FDG PET-CT performed on tumor-bearing SCID mice receiving paclitaxel, D1143, or vehicle at D25 (week of treatment). Mean aorta SUV (left panel) and mean tumor SUV (right panel) have been measured every 5 seconds for 240 seconds. (c) Dynamic [18F]-FDG PET-CT performed on tumor-bearing SCID mice receiving paclitaxel, D1143, or vehicle at D32 (1 week after treatment). Mean aorta SUV (left panel) and mean tumor SUV (right panel) have been measured every 5 seconds for 240 seconds.

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